Fig. 5

Flowchart for the creation of the bAge predictor. First, DNAm data originating from Generation Scotland and six external datasets was pre-processed. GrimAge components and 109 protein EpiScores were generated within each cohort. A Cox PH elastic net regression model of time to all-cause mortality (with 20-fold CV) was trained in Generation Scotland with the GrimAge components and EpiScores as possible features. The model that maximised Harrell’s C index was tested on the six external datasets