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Fig. 4 | Genome Medicine

Fig. 4

From: Single-cell transcriptomic analysis reveals tumor cell heterogeneity and immune microenvironment features of pituitary neuroendocrine tumors

Fig. 4

PIT1-negative tumor epithelial cells. a Heatmap showing the expression of differentially expressed genes in each cluster. b Multiplex immunohistochemical staining of GZMK (red) and TPIT (yellow) in corticotroph tumors. The thickness of the sections is 4 μm. Scale bar: 20 μm. c Inferred developmental trajectory of clusters T09 and T12 by RNA velocity. d GSEA plot showing the pathway enriched in cluster T12 over other clusters. e Bubble heatmap showing the pathway marker genes of each cluster. f Violin plots showing the expression of response to type I interferon pathway marker genes of each cluster

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Genome Medicine

ISSN: 1756-994X

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