Your privacy, your choice

We use essential cookies to make sure the site can function. We also use optional cookies for advertising, personalisation of content, usage analysis, and social media.

By accepting optional cookies, you consent to the processing of your personal data - including transfers to third parties. Some third parties are outside of the European Economic Area, with varying standards of data protection.

See our privacy policy for more information on the use of your personal data.

for further information and to change your choices.

You are viewing the site in preview mode

Skip to main content
Fig. 4 | Genome Medicine

Fig. 4

From: Rare subclonal sequencing of breast cancers indicates putative metastatic driver mutations are predominately acquired after dissemination

Fig. 4

CCF estimates of putative metastatic driver mutations within primary and metastatic tumors. Estimated posterior distributions of CCF (violin plots) in primary tumor blocks (PI and PII) and metastatic tumor blocks (MI, MII, MIII) for (red) metastatic driver mutations that were detected by UDS-UMI/UDG within rare subclones of the primary tumor and (blue) metastatic driver mutations that were not detected within the primary tumor. Distribution height indicates the range of possible CCF values, with the widest point indicating the most likely estimate, using each possible number of mutant alleles (multiplicity factor). Dashed lines indicate a clonal mutation (CCF = 1). Within one metastatic tumor block in patient P11, one mutation did not reach required sequencing thresholds and is labeled in grey. No distributions are shown for mutations that were not detected within primary tumor blocks

Back to article page

Genome Medicine

ISSN: 1756-994X

Contact us