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Fig. 1 | Genome Medicine

Fig. 1

From: DNA methylation memory of pancreatic acinar-ductal metaplasia transition state altering Kras-downstream PI3K and Rho GTPase signaling in the absence of Kras mutation

Fig. 1

Genetically engineered mouse model of inducible acinar-specific KLF4 expression for induction of acinar-ductal metaplasia (ADM). A Schematic of Ptf1a-rtTA, TRE-KLF4 (AK) model and doxycycline administration schedule. TRE: Tet-response element. IP: Intraperitoneal. B Representative hematoxylin and eosin staining of normal control, and day 2, day 4, and day 7 pancreata as in administration schedule in A. Blue arrows: normal ducts. Yellow arrows: ADM. Scale bar: 200 µm. C Relative mRNA expression of murine Krt19 and human KLF4 as quantified by qRT-PCR. n = 2 mice. p-values: two-sided t-test. Error bars: SD

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Genome Medicine

ISSN: 1756-994X

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