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Fig. 3 | Genome Medicine

Fig. 3

From: DNA methylation memory of pancreatic acinar-ductal metaplasia transition state altering Kras-downstream PI3K and Rho GTPase signaling in the absence of Kras mutation

Fig. 3

Gene expression patterns during AK ADM. A UMAP projection of all AK mouse Visium ST spots (n = 31,620 spots). Cell types assigned via canonical marker gene expression. B UMAP projection of AK mouse exocrine Visium ST spots only, labeled by cell type (left) and timepoint (right). C Relative expression level of canonical ADM marker genes in acinar and/or ADM spots at each timepoint. D Selected significantly enriched gene sets from Reactome 2022 Fisher’s GSEA performed on the 1412 genes significantly upregulated in highly pure ADM spots relative to highly pure acinar spots. Normal acinar, n = 4 mice; day 2 ADM, n = 2 mice; day 4 ADM, n = 2 mice; day 7 ADM, n = 2 mice

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Genome Medicine

ISSN: 1756-994X

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