Fig. 5
A A childhood-onset asthma-specific locus at chromosome 1q25.1. From top to bottom, the first two tracks show the −log10 p-values from GWAS and PIPs from fine-mapping, respectively. Each point is a SNP, and assayed SNPs are denoted by larger squares. Different colors are used in the PIP track to represent different LD blocks. The two SNPs in candidate enhancers, rs78037977 and rs11811856, are highlighted in red. The next five tracks display chromatin accessibility from (sn)ATAC-seq of different cell lineages, with each dark blue vertical bar showing the location of an OCR. The next three tracks show chromatin interactions from PCHi-C of different cells, where the loops from the distal candidate enhancer to TNFSF4 promoter in all three cell types are highlighted in red. The last track shows the genes at the locus. BICs: blood immune cells, ASMCs: airway smooth muscle cells, BECs: bronchial epithelial cells. B A childhood-onset asthma-specific locus at chromosome 19q13.11. The PCHi-C loops from the candidate enhancer to the CEBPA promoter in blood immune cells and bronchial epithelial cells are highlighted in red