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Fig. 1 | Genome Medicine

Fig. 1

From: Multi-omics analysis reveals immunosuppression in oesophageal squamous cell carcinoma induced by creatine accumulation and HK3 deficiency

Fig. 1

Overview of the experimental strategy, and proteomic landscape of oesophageal squamous cell carcinoma (ESCC) compared with NATs. A Overview of the experimental strategy, image created with BioRender.com, with permission. B Principal component analysis (PCA) of the proteome. Red, tumours; blue, NATs. C Number of proteins identified in tumours (red dots) and NATs (blue dots). The 95% confidence intervals are shown by the hidden region. D Heatmap showing the differentially expressed proteins in tumours and NATs. Significantly up-regulated and down-regulated pathways are shown on the right. E Heatmap showing the proteins associated with patient survival in these significantly changed pathways, and log2-based hazard ratio are shown on the right. HR: hazard ratio for OS. F Representative proteins of four biological pathways and their relationship with prognosis (FDR-corrected log-rank P values). The cut-off values of each protein are as follows: SNRPB (18.1421), SF3A1 (16.6450), EIF2S1 (18.6551), DNAJC10 (13.1860), DLD (17.6574), BCKDHA (15.9849), COX6B1 (17.2751), UQCRC1 (18.0475). See also Fig. S1, S2 and Table S1, S3, S4

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Genome Medicine

ISSN: 1756-994X

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