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Fig. 2 | Genome Medicine

Fig. 2

From: A multi-omic approach implicates novel protein dysregulation in post-traumatic stress disorder

Fig. 2

Network Co-expression analysis of proteomics data. A Module-trait correlation between protein expression correlations in the DLPFC of PTSD brains and demographic features (PrimaryDx, age of death, PMI, sex, ancestry). Color in each cell reflects correlation between module eigenprotein and PrimaryDx and the number represents significance (− log10(P-value)) of that correlation. Module names are abbreviated as color codes only. B Boxplots of eigenproteins and volcano plots of differential expression patterns of the proteins in PTSD-associated modules PTSD-PM-skyblue (left) and red (right) (vertical dash lines indicate log10(fold change) = ± 0.18. Module PTSD-PM-skyblue, P = 0.03; module PTSD-PM-red, P = 0.04. P indicates eigenprotein change significance between PTSD and CON. C Cell type enrichment analysis showing the enrichment of cell type markers in protein modules. Brown dashed line indicates significantly enriched markers, P < 0.05

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Genome Medicine

ISSN: 1756-994X

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