Fig. 3
From: A multi-omic approach implicates novel protein dysregulation in post-traumatic stress disorder
Gene expression and transcriptome network analysis of PTSD cortical regions. A Volcano plots showing DEGs in DLPFC (left) and sgPFC (right) of PTSD cortical regions. Red (P < 0.05) indicate upregulated genes and blue (P < 0.05) indicate downregulated ones. Red lines indicate P-value = 0.05 and black lines indicate |log fold change| > 0.18. B Pathway enrichment analysis of differentially expressed genes in PTSD and MDD DLPFC and their overlap with sgPFC. C Enrichment of DEGs and cell types in gene modules constructed by WGCNA for DLPFC (top) and sgPFC (bottom). Color indicates significance of enrichment (−log10(P-value)). Module names are abbreviated as indices only. Comparison of transcriptional and protein differential expression are shown in PTSD DLPFC (D) and sgPFC (E))